Lopez N J, Belvederessi M, de la Sotta R
J Periodontol. 1980 Oct;51(10):582-93. doi: 10.1902/jop.1980.51.10.582.
The inflammatory potential of diseased cementum was studied by implanting 70 autogenous fragments from periodontally involved roots into the mucosa of 56 patients. The implants were divided into groups depending upon the type of preparation the root received prior to implantation. Fifteen healthy root fragments implanted into 15 patients served as controls. Histologic results showed that implanted fragments from roots that had been scaled caused the most response with acute inflammation up to 14 days and chronic inflammation to 21 days. In cases in which these fragments were autoclaved the acute inflammation was not as severe. In the cases in which the roots were planed and autoclaved, even less acute inflammation was seen in the 7-day specimens while some chronic inflammation persisted in the 21-day specimens. Implants from healthy roots evoked no response. The inflammation caused by the autoclaved diseased cementum was attributed to thermo-stable endotoxin. It was concluded that in advanced periodontal disease it is necessary to remove all of the cementum exposed to the pocket to eliminate its potential for inducing inflammation.
通过将70个来自牙周病牙根的自体碎片植入56例患者的黏膜中，研究了患病牙骨质的炎症潜能。根据植入前牙根接受的制备类型，将植入物分组。将15个健康牙根碎片植入15例患者体内作为对照。组织学结果显示，来自已刮治牙根的植入碎片引起的反应最大，急性炎症持续至14天，慢性炎症持续至21天。在这些碎片经过高压灭菌的情况下，急性炎症不那么严重。在牙根经过平整和高压灭菌的情况下，7天标本中急性炎症更轻，而21天标本中仍有一些慢性炎症。来自健康牙根的植入物未引起反应。高压灭菌的患病牙骨质引起的炎症归因于热稳定内毒素。得出的结论是，在晚期牙周病中，有必要去除暴露于牙周袋的所有牙骨质，以消除其诱发炎症的潜能。
