Irvine W J, Di Mario U, Guy K, Borsey D Q
J Clin Lab Immunol. 1980 Sep;4(2):87-9.
The sera of 33 type I diabetics found to have pancreatic IgG antibodies to the cytoplasm of pancreatic islet cells (ICAb) at three or more years after diagnosis were tested for immune complexes (AgAb), insulin antibodies and thyroid and gastric cytoplasmic antibodies, and the subjects were HLA typed. Sera from 69 insulin treated diabetics of comparable duration of disease and without ICAb at the time of study were also included in the investigation. The prevalence of AgAb in patients with persistent ICAb was found to be 52% in comparison with 19% of ICAb negative diabetics (p < 0.001) and 10% of normal blood donors (p < 0.0005). AgAb positivity was increased, but not significantly, in HLA-B8 positive compared to B8 negative ICAb persisters. There was a significant negative correlation between AgAb levels and insulin antibody titres. Circulating AgAb were not significantly correlated with the presence of either thyroid or gastric cytoplasmic antibodies.
对33例I型糖尿病患者的血清进行检测，这些患者在确诊三年或更长时间后被发现存在针对胰岛细胞胞质的胰腺IgG抗体（ICAb），检测项目包括免疫复合物（AgAb）、胰岛素抗体以及甲状腺和胃胞质抗体，并对这些受试者进行HLA分型。研究还纳入了69例病程相当且在研究时无ICAb的接受胰岛素治疗的糖尿病患者的血清。结果发现，持续存在ICAb的患者中AgAb的患病率为52%，相比之下，ICAb阴性的糖尿病患者为19%（p<0.001），正常献血者为10%（p<0.0005）。与B8阴性的ICAb持续存在者相比，HLA - B8阳性者的AgAb阳性率有所升高，但无显著差异。AgAb水平与胰岛素抗体滴度之间存在显著负相关。循环AgAb与甲状腺或胃胞质抗体的存在无显著相关性。
