Irvine W J, Sawers J S, Feek C M, Prescott R J, Duncan L J
Endocrine Unit/Immunology Laboratories, Royal Infirmary, Edinburgh.
J Clin Lab Immunol. 1979 Apr;2(1):23-6.
The sera of 160 diabetics who were well controlled by oral hypoglycaemic agents (OHA) for at least three months after diagnosis were tested for pancreatic islet cell antibodies (ICAb) either at diagnosis or within two years after diagnosis. 129 were non-obese at diagnosis and of these ICAb was detected in the sera in 20 (16%). 31 were obese at diagnosis and of these ICAb was detected in the sera in three (10%). All of the 160 diabetics were insulin independent at the time of testing the serum for ICAb. The presence of ICAb was associated with a high probability of becoming insulin dependent, calculated from actuarial statistics. 86% of ICAb positive patients initially controlled on OHA may be expected to be insulin dependent at five years from diagnosis as compared to 18% of ICAb negative patients. Obesity at diagnosis did not significantly affect the probability of becoming insulin dependent. ICAb positive diabetes controlled by OHA can be regarded as a less severe form of insulin-dependent (Type I) diabetes.
对160名糖尿病患者的血清进行检测，这些患者在诊断后至少三个月内通过口服降糖药（OHA）得到良好控制，在诊断时或诊断后两年内检测胰岛细胞抗体（ICAb）。129名患者在诊断时非肥胖，其中20名（16%）血清中检测到ICAb。31名患者在诊断时肥胖，其中3名（10%）血清中检测到ICAb。在检测血清ICAb时，所有160名糖尿病患者均不依赖胰岛素。根据精算统计，ICAb的存在与转为依赖胰岛素的高概率相关。预计诊断后五年，最初通过OHA控制的ICAb阳性患者中有86%会依赖胰岛素，而ICAb阴性患者中这一比例为18%。诊断时肥胖对转为依赖胰岛素的概率没有显著影响。由OHA控制的ICAb阳性糖尿病可被视为胰岛素依赖型（I型）糖尿病的一种较轻形式。
