Alexander E A, Churchill S, Bengele H H
Kidney Int. 1980 Aug;18(2):173-8. doi: 10.1038/ki.1980.126.
We believe that in pregnant rats, GFR is elevated at term, whereas renal plasma flow appears not to be increased. The mechanism for this increment is unclear, as is the specific time during gestation when renal hemodynamics increase. Rats increase their salt appetite and significantly positive sodium balance occurs, which is most pronounced during the last week of gestation. The retained sodium is distributed in part to the products of conception and in part to the mother, particularly in increasing her extracellular fluid volume. Although chronic volume expansion is present, absolute tubular sodium reabsorption remains elevated. The mechanism for this elevated tubular reabsorption appears no to be related to aldosterone because reduction or inhibition of this mineralocorticoid does not affect sodium balance significantly.
我们认为，妊娠大鼠足月时肾小球滤过率（GFR）升高，而肾血浆流量似乎并未增加。这种增加的机制尚不清楚，妊娠期肾血流动力学增加的具体时间也不清楚。大鼠的盐食欲增加，钠平衡显著呈正，这在妊娠最后一周最为明显。潴留的钠部分分配给妊娠产物，部分分配给母体，特别是增加其细胞外液量。尽管存在慢性容量扩张，但肾小管钠重吸收绝对值仍升高。这种肾小管重吸收升高的机制似乎与醛固酮无关，因为这种盐皮质激素的减少或抑制对钠平衡没有显著影响。
