Nordin B E, Jones M M, Crilly R G, Marshall D H, Brooke R
Maturitas. 1980 Oct;2(3):247-51. doi: 10.1016/0378-5122(80)90009-2.
A placebo-controlled trial has shown that 15 microgram of ethinyl oestradiol is as effective as 25 microgram daily in reducing both menopausal symptoms and the urinary excretion of calcium and hydroxyproline. Norethisterone 5 mg daily also showed a significant reduction in the climacteric symptoms but was less effective than either of the ethinyl oestradiol doses.
一项安慰剂对照试验表明，15微克炔雌醇在减轻更年期症状以及减少钙和羟脯氨酸的尿排泄方面与每日25微克的效果相同。每日5毫克炔诺酮也使更年期症状显著减轻，但效果不如任何一种炔雌醇剂量。
