Changes in lysosomal enzymes of peritoneal exudate cells in albino rats and Mastomys natalensis during Plasmodium berghei infection.

Activities of certain lysosomal enzymes of peritoneal exudate cells were followed during Plasmodium berghei infection in two experimental hosts. In albino rats, where sterile immunity against the infection develops, levels of beta-D-glucuroniodase and acid phosphatase activities were increased several times the normal values. On the other hand, in Mastomys natalensis, which succumbs to infection, levels of both the enzymes decreased considerably. Cathepsin D activity did not change to a significant extent in either host.