Acute effects of viloxazine HCl and flurazepam when given alone and in combination on sleep EEG: a double-blind interaction study with normals.

Viloxazine, an aryl-oxypropanolamine type of beta-adreno-receptor antagonist, has been used in the treatment of depression. In a double-blind drug interaction study with flurazepam, a commonly used benzodiazepine hypnotic, viloxazine administered alone decreased the amount of time spent in REM sleep, increased the amount of time in the "light" stages of sleep, and increased the number of transitions to awake. However, no interactive effects of the combined administration of viloxazine and flurazepam could be detected.