• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过全淋巴照射的同种异体骨髓移植纠正小鼠的酶缺乏症。

Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation.

作者信息

Slavin S, Yatziv S

出版信息

Science. 1980 Dec 5;210(4474):1150-2. doi: 10.1126/science.7003711.

DOI:10.1126/science.7003711
PMID:7003711
Abstract

Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (>90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.

摘要

在异基因骨髓移植后且出现移植物抗宿主病的小鼠中，酶缺乏得到了纠正。对β-葡萄糖醛酸酶缺陷的C3H/HeJ小鼠进行了全身淋巴照射。将来自BALB/c的正常骨髓细胞（30×10⁶）移植到C3H/HeJ嵌合体中（循环供体类型细胞>90%），未发生移植物抗宿主病。在肝脏和血浆中检测发现，所有嵌合体中的β-葡萄糖醛酸酶活性均升高至正常水平。在7个月的观察期内活性一直保持。

相似文献

1
Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation.通过全淋巴照射的同种异体骨髓移植纠正小鼠的酶缺乏症。
Science. 1980 Dec 5;210(4474):1150-2. doi: 10.1126/science.7003711.
2
Long-term enzyme replacement therapy in beta-glucuronidase--deficient mice by allogeneic bone marrow transplantation.通过同种异体骨髓移植对β-葡萄糖醛酸酶缺陷小鼠进行长期酶替代治疗。
J Lab Clin Med. 1982 Jun;99(6):792-7.
3
Correction of lysosomal enzyme deficiency in various organs of beta-glucuronidase-deficient mice by allogeneic bone marrow transplantation.通过同种异体骨髓移植纠正β-葡萄糖醛酸酶缺陷小鼠各器官中的溶酶体酶缺乏症。
Transplantation. 1987 May;43(5):609-14. doi: 10.1097/00007890-198705000-00001.
4
In vivo administration of interleukin-6 in murine allogeneic bone marrow chimeras: early and delayed enhancement of hematopoiesis accompanied with split tolerance but not with graft-versus-host disease.在小鼠同种异体骨髓嵌合体中体内给予白细胞介素-6：造血功能早期和延迟增强，伴有分裂耐受但不伴有移植物抗宿主病。
Immunobiology. 1994 Jun;190(4-5):346-67. doi: 10.1016/S0171-2985(11)80607-8.
5
Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.使用分次全身淋巴照射诱导成年小鼠特异性组织移植耐受：同种异体骨髓和皮肤移植的长期存活
J Exp Med. 1977 Jul 1;146(1):34-48. doi: 10.1084/jem.146.1.34.
6
Enhancement of BM allografting from C57BL/6 'nude' mice into C3H/HeJ recipients by tolerized T cells from (C57BL/6-->C3H/HeJ) and (C3H/HeJ-->C57BL/6) chimeras.通过来自（C57BL/6→C3H/HeJ）和（C3H/HeJ→C57BL/6）嵌合体的耐受T细胞增强从C57BL/6“裸”小鼠到C3H/HeJ受体的骨髓同种异体移植。
Bone Marrow Transplant. 1993 Jul;12(1):15-20.
7
Effect of intrasplenic injection of allogeneic bone marrow cells on the survival of lethally X-irradiated mice.脾内注射同种异体骨髓细胞对受致死剂量X射线照射小鼠存活的影响。
Transplantation. 1983 Jan;35(1):19-24. doi: 10.1097/00007890-198301000-00005.
8
Effects of interleukin-6 on hematopoiesis in allogeneic and syngeneic bone marrow chimeras.白细胞介素-6对同种异体和同基因骨髓嵌合体中造血作用的影响。
Immunobiology. 1994 Aug;191(1):21-37. doi: 10.1016/S0171-2985(11)80265-2.
9
Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans.供体CD8细胞可预防小鼠的异基因骨髓移植排斥反应：对人类骨髓移植的潜在意义。
J Exp Med. 1993 Aug 1;178(2):703-12. doi: 10.1084/jem.178.2.703.
10
Long-term effects of bone marrow transplantation on lysosomal enzyme replacement in beta-glucuronidase-deficient mice.骨髓移植对β-葡萄糖醛酸酶缺陷小鼠溶酶体酶替代的长期影响。
J Inherit Metab Dis. 1992;15(6):899-910. doi: 10.1007/BF01800230.

引用本文的文献

1
Bone marrow transplantation does not ameliorate the neurologic symptoms in mice deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT).骨髓移植并不能改善次黄嘌呤鸟嘌呤磷酸核糖转移酶（HPRT）缺陷小鼠的神经症状。
Metab Brain Dis. 1999 Mar;14(1):57-65. doi: 10.1023/a:1020661514514.
2
Bone marrow transplantation for Niemann-Pick mice.尼曼-匹克病小鼠的骨髓移植
J Inherit Metab Dis. 1983;6(3):129-30. doi: 10.1007/BF01800746.
3
Lysosome lipid storage disorder in NCTR-BALB/c mice. III. Isolation and analysis of storage inclusions from liver.
NCTR-BALB/c小鼠中的溶酶体脂质贮积症。III. 肝脏中贮积内含物的分离与分析。
Am J Pathol. 1982 Aug;108(2):160-70.
4
The use of total lymphoid irradiation for allogeneic bone marrow transplantation in animals and man.全身淋巴照射在动物和人类同种异体骨髓移植中的应用。
Surv Immunol Res. 1985;4(3):238-52. doi: 10.1007/BF02918677.
5
Effect of bone marrow transplantation on enzyme levels and clinical course in the neurologically affected twitcher mouse.骨髓移植对神经受累的颤抖小鼠酶水平及临床病程的影响。
J Clin Invest. 1988 Jun;81(6):1790-4. doi: 10.1172/JCI113521.
6
Long-term effects of bone marrow transplantation in dogs with mucopolysaccharidosis I.骨髓移植对黏多糖贮积症I型犬的长期影响。
Am J Pathol. 1989 Mar;134(3):677-92.
7
Long-term effects of bone marrow transplantation on lysosomal enzyme replacement in beta-glucuronidase-deficient mice.骨髓移植对β-葡萄糖醛酸酶缺陷小鼠溶酶体酶替代的长期影响。
J Inherit Metab Dis. 1992;15(6):899-910. doi: 10.1007/BF01800230.