Prange C H, Kessler M, Bach D, Huth F
Z Exp Chir. 1980;13(1):28-37.
This paper reports of experimental xenografting of kidneys in closely related species (fox-dog) modifying primary graft rejection by single i.v. injection of donorspecies-specific lymphocyte antigen in soluble form. Papain treatment was used to separate histocompatibility antigens from lymphocytes of donors. This antigen, in vitro, is capable of reducing cytotoxicity of xeno-antisera by adsorption of their lymphocytotoxic antibodies. A single intraoperative i.v. injection of this antigen to the transplant recipients results in the subsequent failure of humoral antibody production, thus this antigen-mediated effect is thought to be a state of B-cell tolerance. Survival times are more than doubled in comparison to untreated controls and last in average 14.6 +/- 1.74 days (n = 5). Histological studies demonstrate rather well conserved renal parenchym with sporadic infiltrations of round cells.
本文报道了在密切相关物种（狐 - 犬）间进行肾脏异种移植的实验，通过单次静脉注射可溶性形式的供体物种特异性淋巴细胞抗原改变原发性移植排斥反应。采用木瓜蛋白酶处理从供体淋巴细胞中分离组织相容性抗原。该抗原在体外能够通过吸附其淋巴细胞毒性抗体来降低异种抗血清的细胞毒性。在手术中对移植受体单次静脉注射这种抗原会导致随后体液抗体产生失败，因此这种抗原介导的效应被认为是一种B细胞耐受状态。与未处理的对照组相比，存活时间延长了一倍多，平均持续14.6±1.74天（n = 5）。组织学研究表明肾实质保存相当良好，有散在的圆形细胞浸润。
