Prange C H, Kessler M, Bach D
Urol Int. 1980;35(2):105-11. doi: 10.1159/000280310.
This paper reports about experimental xenografting of kidneys in closely related species (fox-dog) modifying primary rejection by treatment of the recipients with anti-donor lymphocyte globulin (ADLG). In respect of the phylogenetic constellations, ADLG contains lymphocytotoxic and hemagglutinating antibodies reactive in vitro with lymphocytes and erythrocytes of foxes as well as of dogs. Furthermore, donor species-specific papain-separated lymphocyte antigen is capable of reducing cytotoxicity of ADLG by adsorption of its lymphocytotoxic antibodies. In vivo ADLG, used as single therapy, has an immunosuppressive effect on kidney graft survival, which results in significant prolongation of mean survival time (9.6 +/- 1.5 days, n = 5).
本文报道了在密切相关的物种（狐狸-狗）之间进行肾脏异种移植的实验，通过用抗供体淋巴细胞球蛋白（ADLG）治疗受体来改变初次排斥反应。就系统发育关系而言，ADLG含有在体外能与狐狸和狗的淋巴细胞及红细胞发生反应的淋巴细胞毒性和血凝抗体。此外，供体物种特异性木瓜蛋白酶分离的淋巴细胞抗原能够通过吸附其淋巴细胞毒性抗体来降低ADLG的细胞毒性。在体内，单独使用ADLG对肾移植存活具有免疫抑制作用，这导致平均存活时间显著延长（9.6±1.5天，n = 5）。
