Khazenson L B, Nikolaeva T A, Romanenkova N I, Gennad'eva T Ia
Zh Mikrobiol Epidemiol Immunobiol. 1980 Nov(11):37-42.
The antiadsorptive capacity of secretory IgA to Sh. sonnei was revealed in experiments with Shigella keratoconjunctivitis used as a model. In patients with dysentery caused by Sh. sonnei IgA in coprofiltrates proved to have greater capacity for agglutinating the antigen than serum IgA. The presence of IgA as coproantibodies in these patients sharply decreased the frequency of diagnostic seroconversions. The importance of the above-mentioned properties of SIgA for diagnosis and for protection from infections affecting the organs and tissue coming into contact with the environment are discussed.
以志贺氏菌性角结膜炎为模型进行的实验揭示了分泌型 IgA 对宋内志贺氏菌的抗吸附能力。在由宋内志贺氏菌引起的痢疾患者中，粪便滤液中的 IgA 凝集抗原的能力比血清 IgA 更强。这些患者中作为共同抗体的 IgA 的存在显著降低了诊断性血清学转换的频率。文中讨论了分泌型 IgA 的上述特性对于诊断以及保护免受影响与外界接触的器官和组织的感染的重要性。
