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Dihydrofolate reductase: binding of substrates and inhibitors and catalytic mechanism.

作者信息

Gready J E

出版信息

Adv Pharmacol Chemother. 1980;17:37-102. doi: 10.1016/s1054-3589(08)60007-1.

DOI:10.1016/s1054-3589(08)60007-1
PMID:7004143
Abstract
摘要

相似文献

1
Dihydrofolate reductase: binding of substrates and inhibitors and catalytic mechanism.二氢叶酸还原酶：底物与抑制剂的结合及催化机制
Adv Pharmacol Chemother. 1980;17:37-102. doi: 10.1016/s1054-3589(08)60007-1.
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The charge state of substrates and inhibitors when bound to Lactobacillus casei dihydrofolate reductase [proceedings].与干酪乳杆菌二氢叶酸还原酶结合时底物和抑制剂的电荷状态[会议论文集]
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Dihydrofolate reductase from the L1210 R murine lymphoma. Further studies on the binding of substrates and inhibitors to the enzyme.来自L1210 R小鼠淋巴瘤的二氢叶酸还原酶。关于底物和抑制剂与该酶结合的进一步研究。
J Biol Chem. 1967 Oct 25;242(20):4777-81.
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Dihydrofolate reductase from a reptile, uromastix.
Biochem Soc Trans. 1991 Apr;19(2):193S. doi: 10.1042/bst019193s.
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Calculations by complete neglect of differential overlap (CNDO/2) on dihydrofolic acid: role of N(5) in reduction by dihydrofolate reductase.对二氢叶酸进行全略微分重叠法（CNDO/2）计算：N(5)在二氢叶酸还原酶还原过程中的作用。
Mol Pharmacol. 1977 Nov;13(6):1111-5.
6
Dihydrofolate reductase: the current story.
Nature. 1979 Dec 13;282(5740):674-5. doi: 10.1038/282674a0.
7
The binding of substrates and inhibitors to dihydrofolate reductase.底物和抑制剂与二氢叶酸还原酶的结合。
Biochem Soc Trans. 1975;3(5):630-1. doi: 10.1042/bst0030630.
8
The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition.
Biochem Pharmacol. 1980 Feb 15;29(4):589-95. doi: 10.1016/0006-2952(80)90381-0.
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[Action of tomizine (4-methoxy-6-aminopyrimido (4,5-b) (1,4)thiazine hydrochloride) on the physicochemical properties of the enzymes of folic acid metabolism--dihydrofolate reductase and nonspecific dihydrofolate reductase].托米嗪（4-甲氧基-6-氨基嘧啶并[4,5-b][1,4]噻嗪盐酸盐）对叶酸代谢酶——二氢叶酸还原酶和非特异性二氢叶酸还原酶理化性质的作用
Izv Akad Nauk SSSR Biol. 1983 Sep-Oct(5):766-70.
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High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.高通量筛选鉴定出与二氢叶酸具有竞争性的新型大肠杆菌二氢叶酸还原酶抑制剂。
Bioorg Med Chem Lett. 2003 Aug 4;13(15):2493-6. doi: 10.1016/s0960-894x(03)00480-3.

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