Lazarev K L, Nesterov E N, Belokurenko S P, Shpak S I, Kashel' A F
Arkh Anat Gistol Embriol. 1979 Feb;76(2):39-44.
The size of the renal body in convoluted parts of proximal and distal nephrons has been studied in normal dogs and after section and ligation of the efferent lymphatic vessels in 4 series of experiments (85 dogs). Observations have been made 12 h, 3 and 10--150 days after the operation. Histological, histochemical and morphometric methods have been applied; the level of residual nitrogen has been estimated. In early days of the experiment, the disturbance in lymph drainage has been found to result in edema and albuminous saturation of the connective tissue stroma, granular distrophy of the epithelium in the convoluted tubules of the kidney. After 40--150 days of the experiment, diffuse sclerosis of the connective tissue stroma of the medullar substance and of the pyramids develops. Alterations and disorders in the organ's function on nitrogen discharge are especially pronounced when lymph drainage is disturbed in one kidney, and the other kidney is removed. In such a case, the processes of compensatory hypertrophy are delayed. Morpho-functional alterations are less pronounced after lymph drainage disorders in the compensatory hypertrophic kidney.
在4组实验（共85只狗）中，研究了正常狗以及在切断和结扎输出淋巴管后的狗的近曲和远曲肾单位迂回部分的肾体大小。在手术后12小时、3天以及10 - 150天进行了观察。应用了组织学、组织化学和形态测量方法；估算了残余氮水平。在实验早期，发现淋巴引流障碍会导致结缔组织基质水肿和白蛋白浸润、肾曲管上皮颗粒性营养不良。实验40 - 150天后，髓质和锥体的结缔组织基质出现弥漫性硬化。当一侧肾脏的淋巴引流受到干扰而另一侧肾脏被切除时，器官在氮排泄功能方面的改变和紊乱尤为明显。在这种情况下，代偿性肥大过程会延迟。在代偿性肥大的肾脏中，淋巴引流障碍后形态功能改变不太明显。
