Wright P J, Stelmasiak T, Chamley W A
Aust J Biol Sci. 1980 Aug;33(4):465-9. doi: 10.1071/bi9800465.
Oestradiol-17 beta (40 micrograms intravenously) failed to elicit a surge in plasma LH levels by 13 h after administration in 64% (16 out of 25) Merino ewes about 30 days post partum in the anoestrous season. LH-RH responsiveness and LH-RH priming effect were significantly greater in these ewes than in similar post-partum (n = 9) and non-parturient ewes (n = 3) not treated with oestradiol. This suggests that the failure of the oestrogen-positive feedback effect on LH release in post-partum ewes is not due to a failure of oestradiol action on the pituitary increasing pituitary responsiveness to LH-RH and LH-RH priming effect, but could be due to inadequate release of LH-RH from the hypothalamus.
在产后约30天的乏情季节，给25只美利奴母羊静脉注射17β-雌二醇（40微克），64%（25只中的16只）的母羊在给药后13小时血浆促黄体生成素（LH）水平未出现激增。这些母羊的促性腺激素释放激素（LH-RH）反应性和LH-RH激发效应显著高于未用雌二醇处理的类似产后母羊（n = 9）和未产母羊（n = 3）。这表明产后母羊中雌激素对LH释放的正反馈作用失败，并非由于雌二醇对垂体的作用失败，即垂体对LH-RH的反应性和LH-RH激发效应未增加，而是可能由于下丘脑LH-RH释放不足。
