Fink G, Sheward W J, Charlton H M
J Endocrinol. 1982 Aug;94(2):283-7. doi: 10.1677/joe.0.0940283.
We have investigated the LH response to LH releasing hormone (LH-RH) in female hypogonadal (hpg) mice in which the hypothalamus contains no LH-RH and the pituitary gland contains significantly less LH than in normal mice. Both the releasing action and the priming effect of LH-RH were not significantly different in hpg compared with normal mice. Raised plasma concentrations of oestradiol-17 beta reduced pituitary responsiveness to LH-RH in normal but not in hpg mice. These results show that in the mouse neither long-term exposure to normal levels of LH-RH nor a normal pituitary content of LH are necessary for either the releasing or the priming action of LH-RH.
我们研究了雌性性腺功能减退（hpg）小鼠对促黄体生成素释放激素（LH-RH）的LH反应。在这些小鼠中，下丘脑不含LH-RH，垂体中的LH含量比正常小鼠显著减少。与正常小鼠相比，hpg小鼠中LH-RH的释放作用和启动效应均无显著差异。正常小鼠中升高的血浆17β-雌二醇浓度会降低垂体对LH-RH的反应性，但hpg小鼠中则不会。这些结果表明，在小鼠中，无论是长期暴露于正常水平的LH-RH，还是垂体中正常的LH含量，对于LH-RH的释放或启动作用都不是必需的。
