[人早幼粒白血病细胞系HL60中的胰岛素受体]
[Insulin receptors in the HL60 human promyelocytic leukemic cells line].
作者信息
Palumbo A, Turco G L, Brossa C, D'Alberto M, Giovinazzo B, Pegoraro L
出版信息
Boll Soc Ital Biol Sper. 1980 Jul 15;56(13):1345-9.
PMID:7004462
Abstract
The insulin binding characteristics of human promyelocitic HL60 cell line was studied by the use pf I(125) insulin. The binding activity was found to increase linearily both with the number of cells and with the incubation time. The competition curve with increasing concentration of unlabeled insulin demonstrated of specific receptors. The number of receptors was estimated to be 6.36 . 10(6) per cell.
摘要
利用碘（¹²⁵）胰岛素研究了人早幼粒细胞HL60细胞系的胰岛素结合特性。发现结合活性随细胞数量和孵育时间呈线性增加。随着未标记胰岛素浓度增加的竞争曲线表明存在特异性受体。估计每个细胞的受体数量为6.36×10⁶个。
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