兔肠缺血再灌注和全身缺血再灌注时肺和肝脏中铜和锌含量的变化

Changes of the Cu and Zn contents in lung and liver in intestinal ischemic reperfusion and general ischemic reperfusion in rabbits.

作者信息

Ming Y, Yihling L, Shansheng H, Dianhuang W, Shuqing G, Zhenxing X

机构信息

Department of Pathophysiology, Hebei Medical College, Shijiazhuang, P.R.C.

出版信息

Biol Trace Elem Res. 1993 Oct;39(1):41-7. doi: 10.1007/BF02783808.

DOI:10.1007/BF02783808

PMID:7505098

Abstract

The changes of pulmonary and liver Cu-Zn contents were determined and evaluated in intestinal ischemic reperfusion (IIR) and general ischemic reperfusion (GIR) of rabbits. The contents of pulmonary Zn and liver Cu were found to be lower, and Cu/Zn ratio increased in lung tissue and decreased in liver tissue in IIR. The contents of pulmonary Zn were increased, and the contents of liver Cu were decreased; Cu/Zn ratio also decreased in both tissues in GIR. Pulmonary Cu and liver Zn contents were not changed in IIR and GIR. These results showed that lower or higher Zn in lung tissue and lower Cu in liver tissue were related to the acute tissue injury during IIR and GIR, suggesting that regulating the state of pulmonary Zn and liver Cu should be attempted during the prevention and treatment of both ischemic reperfusions.

摘要

测定并评估了兔肠缺血再灌注（IIR）和全身缺血再灌注（GIR）时肺和肝脏铜锌含量的变化。发现IIR时肺组织锌含量降低，肝脏铜含量降低，肺组织铜/锌比值升高，肝脏组织铜/锌比值降低。GIR时肺组织锌含量升高，肝脏铜含量降低，两个组织的铜/锌比值也降低。IIR和GIR时肺组织铜和肝脏锌含量未发生变化。这些结果表明，肺组织中锌含量降低或升高以及肝脏组织中铜含量降低与IIR和GIR期间的急性组织损伤有关，提示在两种缺血再灌注的防治过程中应尝试调节肺锌和肝脏铜的状态。