Giudicelli J F, Freslon J L, Glasson S, Richer C
Clin Exp Hypertens (1978). 1980;2(6):1083-96. doi: 10.3109/10641968009037162.
Captopril (100mg/kg) administered daily by gavage to young spontaneously hypertensive rats (SHRs) from their 6th to 20th weeks of age almost completely inhibited genetic hypertension development (GHD). This effect was correlated with an early and long-lasting limitation of the progressive increase in peripheral resistance which normally develops in SHRs during their growth. Heart rate, cardiac and systolic indexes remained unchanged, plasma renin concentration was significantly increased and heart weight/body weight ratio was significantly decreased. At last, captopril's GHD preventive effect persisted up to 12 weeks after treatment discontinuation.
从6周龄至20周龄，每天通过灌胃给年轻的自发性高血压大鼠（SHRs）施用卡托普利（100mg/kg），几乎完全抑制了遗传性高血压的发展（GHD）。这种作用与外周阻力的渐进性增加的早期和长期限制相关，外周阻力的渐进性增加在SHRs生长过程中通常会出现。心率、心脏和收缩压指标保持不变，血浆肾素浓度显著增加，心脏重量/体重比显著降低。最后，卡托普利的GHD预防作用在停药后持续长达12周。
