Chadelaud M, Moore N, Berland C, Saligaut C, Daoust M, Chretien P, Boismare F
Clin Exp Hypertens A. 1984;6(6):1179-86. doi: 10.3109/10641968409039590.
Ten consanguine monogamous SHR couples (G1) were treated from their 5th to their 37th week of age with captopril, 50 mg/kg/day i.p. Male rats were treated without interruption. Treatment was withheld in female rats from delivery to weaning. They were compared to ten similar SHR couples which were only daily i.p. injected with the same volume of solvent. Second (G2) generation rats (untreated) were studied. In G1 rats, systolic blood pressure (SBP) and heart weight/body weight (HW/BW) ratio were decreased, while heart rate (HR) was not changed. Plasma renin activity remained unchanged at 37 weeks of age though the treatment was effective. Parental treatment did not reduce SBP and HW/BW ratio in G2 rats. This indicates that reduction of hypertension in SHR is not enough to prevent hypertension development in the offspring of the treated rats.
十对近亲一夫一妻制的自发性高血压大鼠（SHR）夫妇（G1组）在5至37周龄时接受卡托普利治疗，腹腔注射剂量为50毫克/千克/天。雄性大鼠不间断接受治疗。雌性大鼠从分娩到断奶期间停止治疗。将它们与十对类似的SHR夫妇进行比较，后者仅每天腹腔注射相同体积的溶剂。对第二代（G2组）大鼠（未治疗）进行了研究。在G1组大鼠中，收缩压（SBP）和心脏重量/体重（HW/BW）比值降低，而心率（HR）未改变。尽管治疗有效，但在37周龄时血浆肾素活性保持不变。亲代治疗并未降低G2组大鼠的SBP和HW/BW比值。这表明降低SHR的高血压程度不足以预防经治疗大鼠后代的高血压发展。
