Naylor E W, Lebenthal E
Dig Dis Sci. 1980 Dec;25(12):945-59. doi: 10.1007/BF01308046.
In recent years, a number of comprehensive reviews have been written on inherited intestinal polyposis syndromes (1-7), but none has dealt specifically with Gardner's syndrome and none has focused on basic research being carried out in an attempt to understand this syndrome and to improve the medical management of affected patients. A better understanding of this rare genetic disorder is essential for surgeons, gastroenterologists, cancer researchers, and geneticists alike. To the clinician, it poses difficult challenges in management; to the cancer researcher, it presents a rare opportunity to study very early premalignant transformations; and to the geneticist, it poses exciting questions at the cellular, chromosomal, and molecular levels.
近年来，已经有许多关于遗传性肠道息肉病综合征的综合综述发表（1 - 7），但没有一篇专门论述加德纳综合征，也没有一篇聚焦于为理解该综合征及改善对患病患者的医疗管理而开展的基础研究。对于外科医生、胃肠病学家、癌症研究人员和遗传学家而言，更好地了解这种罕见的遗传疾病至关重要。对临床医生来说，它在管理方面带来了艰巨挑战；对癌症研究人员来说，它提供了一个研究极早期癌前病变的难得机会；而对遗传学家来说，它在细胞、染色体和分子层面提出了令人兴奋的问题。
