Itskovitz J, Fisher M, Urbach J, Brandes J M
Eur J Obstet Gynecol Reprod Biol. 1980 Oct;11(2):101-7. doi: 10.1016/0028-2243(80)90015-5.
A prospective double-blind study of antibiotic prophylaxis in 69 patients undergoing total abdominal hysterectomy was conducted. A short, 1-day course of cefazolin prophylaxis effectively decreased febrile morbidity, serious postoperative infections and hospital stay. Resistant infections or delayed infections were not encountered in this series of prophylactically treated patients. There was no difference between the active drug group and the placebo group in the frequency with which aerobic Gram-negative rods and the incidence of cephalosporin-resistant organisms cultured postoperatively.
对69例行全腹子宫切除术的患者进行了一项前瞻性双盲抗生素预防研究。短疗程（1天）的头孢唑林预防有效降低了发热发病率、严重术后感染及住院时间。在这组接受预防性治疗的患者中未出现耐药感染或延迟感染。活性药物组和安慰剂组术后培养出需氧革兰氏阴性杆菌的频率以及头孢菌素耐药菌的发生率没有差异。
