Szydłowska H, Dłuzniewski A
Folia Histochem Cytochem (Krakow). 1978;16(3):233-40.
An attempt was made to apply thalidomide as a block of functional protein groups in histochemical investigations. It was found that thalidomide slightly oxidizes thyrosine and blocks the SH groups mainly in the cytoplasm of rat liver. Contrary to N-ethyl-maleimide, thalidomide does not block the SH groups irreversible, and they can be reactivated with BAL. It is suggested that the teratogenic effect of thalidomide can be connected with the possibility of inactivation of the SH groups by this compound.
曾尝试将沙利度胺用作组织化学研究中功能蛋白基团的阻断剂。发现沙利度胺会轻微氧化酪氨酸，主要阻断大鼠肝脏细胞质中的巯基。与N - 乙基马来酰亚胺不同，沙利度胺不会不可逆地阻断巯基，并且它们可用二巯丙醇重新激活。有人提出，沙利度胺的致畸作用可能与此化合物使巯基失活的可能性有关。
