Skakun N P, Vysotskiĭ I Iu
Antibiotiki. 1983 Sep;28(9):682-6.
It was shown in experiments with albino rats that intoxication with tetracyclines and especially with chlortetracycline and tetracycline lowered the levels of sulfhydryl groups in the blood and liver homogenates of the animals, while the levels of the --S--S-groups increased. Tetracycline is characterized by a lower hepatotoxic action and did not affect the levels of sulfhydryl groups. It is suggested that impairment of lipid metabolism, inhibition of bile production and suppression of tissue respiration and oxidative phosphorylation due to oxidation or binding of SH-groups of enzymes and low molecular substances were the main links in the pathogenesis of liver fatty degeneration induced by tetracycline antibiotics.
对白化大鼠的实验表明，用四环素尤其是金霉素和四环素中毒会降低动物血液和肝脏匀浆中巯基的水平，而二硫键的水平会升高。四环素的特点是肝毒性作用较低，且不影响巯基水平。有人认为，由于酶和低分子物质的巯基氧化或结合导致脂质代谢受损、胆汁生成抑制以及组织呼吸和氧化磷酸化受抑制，是四环素抗生素诱导肝脂肪变性发病机制中的主要环节。
