Rothe G M
Hum Genet. 1980;56(2):129-55. doi: 10.1007/BF00295687.
A survey on the formation of secondary isozymes (= multiple molecular forms of enzymes) is given by means of well-documented enzyme systems. Further examples of a certain type of formation are summarized in tabular form. Eight different classes of enzyme variants deriving from translational processes are discussed. These are: aggregation, polymerization, oxidation and reduction of free SH groups, limited proteolysis, cleavage of carbohydrate residues, deamidation, noncovalent binding of coenzymes, and conformational isomerism. In addition, the intracellular distribution of secondary isozymes is discussed, as are the formation of artificial enzyme variants and the recognition of multiple enzyme forms caused by an exchange of neutral amino acids. About 200 original papers are cited. The reference list was completed in early 1979.
本文借助充分记录的酶系统，对二级同工酶（即酶的多种分子形式）的形成进行了综述。以表格形式总结了某类形成的更多实例。讨论了源自翻译过程的八类不同的酶变体。它们分别是：聚集、聚合、游离巯基的氧化和还原、有限的蛋白水解、碳水化合物残基的裂解、脱酰胺作用、辅酶的非共价结合以及构象异构。此外，还讨论了二级同工酶的细胞内分布，以及人工酶变体的形成和由中性氨基酸交换引起的多种酶形式的识别。引用了约200篇原始论文。参考文献列表于1979年初完成。
