Demedts M, Clément J, Schepers R, van de Woestijne K P
Respiration. 1976;33(3):199-210. doi: 10.1159/000193734.
In 59 patients with respiratory insufficiency due to chronic obstructive pulmonary disease (COPD) the relationship between the state of consciousness, the blood gases and blood ammonia were studied. Interindividually, a significant correlation was found between the encephalopathy and SaO2, PaCO2 or ammonia, and also between the blood gases and ammonia. On the other hand, an intraindividual study, performed on patients with minor cerebral dysfunction, showed that only PaCO2 was significantly correlated with the stage of consciousness. Ammonia did not appear to have a neurotoxic influence. The ammonia level seemed to be influenced primarily by other factors than the blood gases, although there was a borderline influence of SaO2 on aterial ammonia and a significant influence of PaCO2-HCO3 and pH on venous ammonia.
对59例慢性阻塞性肺疾病（COPD）所致呼吸功能不全患者，研究了意识状态、血气和血氨之间的关系。个体间研究发现，脑病与动脉血氧饱和度（SaO2）、动脉血二氧化碳分压（PaCO2）或血氨之间存在显著相关性，血气与血氨之间也存在显著相关性。另一方面，对轻度脑功能障碍患者进行的个体内研究表明，只有PaCO2与意识状态显著相关。氨似乎没有神经毒性作用。血氨水平似乎主要受血气以外的其他因素影响，尽管SaO2对动脉血氨有临界影响，PaCO2 - 碳酸氢根（HCO3）和pH对静脉血氨有显著影响。
