Teixeira F, Gayotto L C, De Brito T
Histopathology. 1978 Jul;2(4):231-7. doi: 10.1111/j.1365-2559.1978.tb01716.x.
Histological features were semi-quantitatively analysed in 60 livers, obtained by necropsy, from patients who died of South American blastomycosis. These findings were classified and correlated with duration of the disease and treatment. Bile-duct lesions were prominent and a particular pattern was found in which segments of bile ducts were "disrupted" and replaced by inflammatory reaction. A classification of the lesions is proposed: Class o--near normal livers; Class I--predominance of necrosis and suppuration; Class II--predominance of tuberculoid granulomas; Class III--portal fibrosis and non-specific infiltrate. There has been no evidence that treatment could induce bile-duct proliferation, fatty change of liver cells, or cholestasis. On the other hand, less fibrosis was found in treated patients. Pathogenesis of the bile-duct lesions is discussed.
对60例死于南美芽生菌病患者尸检获得的肝脏进行组织学特征的半定量分析。这些发现进行了分类，并与疾病持续时间和治疗情况相关联。胆管病变显著，发现一种特殊模式，即胆管节段“中断”并被炎症反应取代。提出了病变的分类：0级——肝脏接近正常；I级——以坏死和化脓为主；II级——以结核样肉芽肿为主；III级——门脉纤维化和非特异性浸润。没有证据表明治疗可诱导胆管增生、肝细胞脂肪变性或胆汁淤积。另一方面，在接受治疗的患者中发现纤维化较少。对胆管病变的发病机制进行了讨论。
