Ivanoff B, André C, Robert D, André F, Fontanges R
Ann Microbiol (Paris). 1980 Sep-Oct;131B(2):153-61.
Oral vaccination with Salmonella typhi-murium M 206 has been shown to confer highly significant protection on BALB/c and low-responder (LR) Biozzi mice a 30 days, but no protection was observed in high-responder (HR) Biozzi mice. None of the three strains showed any evidence of significant protection 10 days after primary vaccination. A correlation was noted between the degree of protection and the results of tests measuring cell-mediated immunity, both in vitro (MIF test), and in vivo (colloidal carbon clearance). Phagocytosis was significantly more active in vaccinated mice, both at days 10 and 30, except in HR mice. MIF production was only found at day 10 in HR mice, and was present at day 30 in both HR and LR mice. Our results emphasize the importance of the role of macrophage phagocytosis in the protection of mice against Salmonella infections.
已证明用鼠伤寒沙门氏菌M 206进行口服疫苗接种，在30天时能为BALB/c和低反应性（LR）Biozzi小鼠提供高度显著的保护，但在高反应性（HR）Biozzi小鼠中未观察到保护作用。在初次接种疫苗10天后，这三种菌株均未显示出任何显著保护的迹象。在体外（MIF试验）和体内（胶体碳清除试验）测量细胞介导免疫的测试结果与保护程度之间存在相关性。在接种疫苗的小鼠中，无论是在第10天还是第30天，吞噬作用都明显更活跃，但HR小鼠除外。MIF产生仅在HR小鼠的第10天被发现，在HR和LR小鼠的第30天均存在。我们的结果强调了巨噬细胞吞噬作用在保护小鼠免受沙门氏菌感染中的重要作用。
