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小麦籽粒免疫荧光抗体能否作为麸质敏感性的指标?

Wheat grain immunofluorescent antibodies as an indication of gluten sensitivity?

作者信息

Kalimo K, Vainio E

出版信息

Br J Dermatol. 1980 Dec;103(6):657-61. doi: 10.1111/j.1365-2133.1980.tb01688.x.

Abstract

An immunofluorescence method using whole sections of wheat grains as the substrate was applied to detect circulating antibodies to wheat gluten in dermatitis herpetiformis patients and in controls. Only IgG class antibodies were detected. From dermatitis herpetiformis patients 22% had these antibodies as had 22% of the atopic dermatitis group. Among the controls who had no skin problems 12% were faintly positive. It is evident that the test as such is non-specific and does not have diagnostic significance in dermatitis herpetiformis.

摘要

采用以完整麦粒切片为底物的免疫荧光法,检测疱疹样皮炎患者及对照者血清中抗麦麸质抗体。仅检测到IgG类抗体。疱疹样皮炎患者中22%有此类抗体,特应性皮炎组也有22%有此类抗体。在无皮肤问题的对照组中,12%呈弱阳性。显然,该检测本身不具有特异性,对疱疹样皮炎无诊断意义。

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