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原发性胆汁性肝硬化循环免疫复合物中胆汁抗原的鉴定

Identification of biliary antigens in circulating immune complexes in primary biliary cirrhosis.

作者信息

Amoroso P, Vergani D, Wojcicka B M, McFarlane I G, Eddleston A L, Tee D E, Williams R

出版信息

Clin Exp Immunol. 1980 Oct;42(1):95-8.

PMID:7006876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537061/
Abstract

The presence of biliary tract antigens in circulating immune complexes from patients with primary biliary cirrhosis (PBC) was investigated. Concentrations of immune complexes in PBC sera, measured by the Raji cell immunoassay, ranged from 58 to greater than 1,000 microgram/ml, but did not correlate with disease activity. Immunofluorescent staining of complexes bound to Raji cells was carried out with guinea-pig antiserum raised against biliary tract antigens. Positive staining reactions were observed with complexes obtained from PBC patients, but not with those obtained from patients with systemic lupus erythematosus or rheumatoid arthritis, indicating that in PBC antigenic components associated with the biliary tract are contained within the complexes.

摘要

对原发性胆汁性肝硬化（PBC）患者循环免疫复合物中胆道抗原的存在情况进行了研究。通过Raji细胞免疫测定法测得的PBC患者血清中免疫复合物的浓度范围为58至大于1000微克/毫升，但与疾病活动度无关。用针对胆道抗原产生的豚鼠抗血清对结合到Raji细胞上的复合物进行免疫荧光染色。从PBC患者获得的复合物观察到阳性染色反应，而从系统性红斑狼疮或类风湿性关节炎患者获得的复合物则未观察到阳性染色反应，这表明在PBC中，与胆道相关的抗原成分包含在复合物中。

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A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes.化脓性链球菌与人类成纤维细胞、内皮细胞和星形胶质细胞之间的交叉反应。
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Clin Exp Immunol. 1978 Oct;34(1):19-27.
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Clin Exp Immunol. 1978 Feb;31(2):150-7.
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N Engl J Med. 1978 Feb 2;298(5):233-7. doi: 10.1056/NEJM197802022980502.
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Gastroenterology. 1979 Jun;76(6):1333-40.
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The Raji cell radioimmune assay for detecting immune complexes in human sera.用于检测人血清中免疫复合物的拉吉细胞放射免疫测定法。
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Is primary biliary cirrhosis an immune complex disease?
Lancet. 1977 Dec 17;2(8051):1261-3. doi: 10.1016/s0140-6736(77)92666-6.

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