Steel J M, Duncan L J
Diabetes Care. 1980 Jul-Aug;3(4):557-60. doi: 10.2337/diacare.3.4.557.
Experience in a large diabetic clinic has confirmed the suspicion that insulin-dependent diabetic women are at considerably increased risk of thromboembolic disease if they take combined estrogen/progestogen oral contraceptive preparations. The most obvious alternative, an intrauterine device, is associated with an unexpectedly high failure rate, probably because of an unusual metabolic interaction with the diabetic endometrium. In a small group of diabetic women the progestogen-only pill was found to be a successful form of contraception not associated with any side effects except for menstrual irregularities. For most diabetic women the choice of contraceptive should therefore be between a progestogen-only pill and a mechanical method. Female sterilization and injectable progesterone each have their place in particular circumstances. Careful counseling of each patient is essential to ensure the best choice of contraceptive and correct application of the chosen method.
一家大型糖尿病诊所的经验证实了这样一种怀疑,即胰岛素依赖型糖尿病女性如果服用雌激素/孕激素联合口服避孕药,患血栓栓塞性疾病的风险会大幅增加。最明显的替代方法——宫内节育器,其失败率却出奇地高,这可能是由于与糖尿病子宫内膜存在异常的代谢相互作用。在一小群糖尿病女性中,发现仅含孕激素的避孕药是一种成功的避孕方式,除月经不规律外无任何副作用。因此,对于大多数糖尿病女性来说,避孕方式的选择应在仅含孕激素的避孕药和机械避孕方法之间。女性绝育和注射用孕激素在特定情况下各有其适用之处。对每位患者进行仔细的咨询至关重要,以确保能做出最佳的避孕选择并正确应用所选方法。