Koeffler H P, Gale R P, Golde D W
Exp Hematol. 1980 Mar;8(3):271-7.
To determine the half-life of circulating myeloid colony-forming cells (CFUc) in man, we studied circulating CFUc in the blood of transplant recipients after the infusion of donor marrow. The agar culture technique was used to clone peripheral blood granulocyte-monocyte progenitors. Circulating CFUc were rare before donor marrow infusion. After infusion of a large number of donor progenitor cells, there was a rapid, linear decrease in myeloid colony-forming cells in the patients' blood. The mean half-life for the circulating CFUc was 4.6 h. No correlation was noted between maximum number of circulating CFUc and the disappearance rate from the blood. A rapid increase in circulating CFUc occurred simultaneously with marrow engraftment.
为了确定人体循环髓系集落形成细胞（CFUc）的半衰期，我们研究了输注供体骨髓后移植受者血液中的循环CFUc。采用琼脂培养技术克隆外周血粒细胞-单核细胞祖细胞。在输注供体骨髓之前，循环CFUc很少见。输注大量供体祖细胞后，患者血液中的髓系集落形成细胞迅速呈线性下降。循环CFUc的平均半衰期为4.6小时。循环CFUc的最大数量与从血液中的消失率之间未发现相关性。循环CFUc的迅速增加与骨髓植入同时发生。
