Haralambie E, Linzenmeier G, Nowrousian M, Schäfer R, Schmidt C G
Immun Infekt. 1980;8(3):89-95.
Patients suffering from acute leukemia were treated by bone marrow transplantation under strict gnotobiotic conditions. The microbiological surveillance was performed during three phases: the admission phase, the phase of decontamination and reverse isolation and the reconventionalisation phase. During the second phase no infections of exogenous origine occurred. All clinically manifest infections in this phase were induced by unsuppressed endogenous bacteria. In our study the bacteria of oropharynx was the main source of infections therefore this biotop deserves special attention during the microbiological surveillance of the immune compromised host. In leukemia patients selective decontamination will be the method of choice, but considering the possibility of GvHR in patients with bone marrow transplantation a complete decontamination should be achieved.
患有急性白血病的患者在严格的无菌条件下接受骨髓移植治疗。微生物监测分三个阶段进行：入院阶段、净化及反向隔离阶段和恢复常规阶段。在第二阶段未发生外源性感染。该阶段所有临床表现出的感染均由未受抑制的内源性细菌引起。在我们的研究中，口咽部细菌是感染的主要来源，因此在免疫受损宿主的微生物监测期间，这个生态位值得特别关注。对于白血病患者，选择性净化将是首选方法，但考虑到骨髓移植患者发生移植物抗宿主反应（GvHR）的可能性，应实现完全净化。
