Tyce G M, Ogg J, Owen C A
J Neurochem. 1981 Feb;36(2):640-50. doi: 10.1111/j.1471-4159.1981.tb01637.x.
The concentration of glutamine increases in the brain after hepatectomy. In the present studies the conversion of intravenously given [14C]acetate to [14C]glutamate and [14C]glutamine was studied in control rats and in rats at 6 h after complete hepatectomy. The incorporation of label into glutamate was only slightly inhibited, but the further incorporation into glutamine was greatly inhibited, after hepatectomy. These data, and previous data using [14C]glucose as precursor, indicate that synthesis of glutamine in brain is inhibited after hepatectomy, and suggest that its concentration must increase because degradation is inhibited to an even greater extent.
肝切除术后大脑中谷氨酰胺的浓度会升高。在本研究中，对对照组大鼠以及完全肝切除术后6小时的大鼠，研究了静脉注射的[¹⁴C]乙酸盐向[¹⁴C]谷氨酸盐和[¹⁴C]谷氨酰胺的转化情况。肝切除术后，标记物掺入谷氨酸盐的过程仅受到轻微抑制，但进一步掺入谷氨酰胺的过程则受到极大抑制。这些数据，以及先前以[¹⁴C]葡萄糖作为前体的研究数据表明，肝切除术后大脑中谷氨酰胺的合成受到抑制，并且表明其浓度升高必定是因为降解受到了更大程度的抑制。
