Syrota A, Pascal O, Crouzel M, Kellershohn C
J Nucl Med. 1981 Feb;22(2):145-8.
Uptake of C-11 chlorpromazine (CPZ) was measured to evaluate the nonrespiratory function of lung in patients. A multiple-indicator dilution technique was used with external detection. Following intravenous bolus injection of C-11 CPZ, with In-113m transferrin as an intravascular reference molecule, counts were recorded with a scintillation camera using two energy windows. The residue functions, R(t), for C-11 CPZ and In-113m transferrin were plotted against time for selected areas of interest, and the CPZ area-weighted extraction, E(t), was computed for the same areas every 250 msec using the formula: E(t) = [RT(t) - RR(t)]/[1 - RR(t)], where RT and RR are the normalized residue functions for CPZ and transferrin, respectively. The initial extraction was 90 +/- 5% in four normal subjects and 64 +/- 7% in six patients with chronic obstructive lung disease (C.O.L.D.), these values being significantly different (p less than 0.001). The large initial extraction of CPZ in a single passage through the pulmonary vasculature resulted from a fixation to membranes, due to its high liposolubility. The lower extraction seen in patients with C.O.L.D. was explained by weaker fixation to lung tissue.
为评估患者肺部的非呼吸功能，对¹¹C-氯丙嗪（CPZ）的摄取情况进行了测量。采用多指示剂稀释技术并进行外部检测。在静脉推注¹¹C-CPZ后，以¹¹³mIn-转铁蛋白作为血管内参考分子，使用闪烁相机通过两个能量窗记录计数。针对选定的感兴趣区域，将¹¹C-CPZ和¹¹³mIn-转铁蛋白的残留函数R(t)绘制成时间的函数图，并使用公式：E(t)=[RT(t)-RR(t)]/[1-RR(t)]，每250毫秒计算相同区域的CPZ面积加权提取率E(t)，其中RT和RR分别是CPZ和转铁蛋白的标准化残留函数。四名正常受试者的初始提取率为90±5%，六名慢性阻塞性肺疾病（C.O.L.D.）患者的初始提取率为64±7%，这些值有显著差异（p<0.001）。由于¹¹C-CPZ的高脂溶性，其单次通过肺血管时的大量初始提取是由于与膜的结合。C.O.L.D.患者中较低的提取率是由于与肺组织的结合较弱所致。
