Differential expression of minor histocompatibiility antigens on the surface of the mouse oocyte and preimplantation developmental stages.

The expression of specific minor histocompatibility antigens on oocytes and preimplantation developmental stages in the mouse has been examined using immunofluorescence. Multi-specific alloantisera in conjunction with serological adsorption and target cells of the appropriate genotype have been used to how that there is differential expression of minor histocompatibility antigens during early development. Detailed analysis showed that antigen expression can be detected on oocytes and zygotes, but not on two-cell stages. From the eight-cell stage to the blastocyst, reactivity with antibody directed against a single specificity could be detected.