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用复方新诺明、多西环素和链霉素治疗急性布鲁氏菌病。一项对比研究(作者译)

[Treatment of acute brucellosis with cotrimoxazole, doxicyclin and streptomycin. A comparative study (author's transl)].

作者信息

Vargas V, Pedreira J D, Clotet B, Juste C, Guardia J, Bacardi R

出版信息

Med Clin (Barc). 1980 Dec 15;75(10):418-20.

PMID:7007755
Abstract

Human brucellosis can be managed with different therapeutic measures. The present study compares the therapeutic efficacy of the classical treatment with streptomycin, doxicyclin and cotrimoxazole, every one of the treatment regimes being applied to 19 patients with acute brucellosis. The results do not demonstrate an advantage of the new association over the classical treatment. Relapses, time elapsed until the patient was afebrile and drug tolerance were similar for both treatments. The classical treatment has a lower cost but the new association implies more patient comfort because the number of pills to be ingested daily is reduced to less than half, a fact that could make it the treatment of choice.

摘要

人类布鲁氏菌病可以通过不同的治疗措施进行管理。本研究比较了经典治疗方案(链霉素、多西环素和复方新诺明)的疗效,每种治疗方案均应用于19例急性布鲁氏菌病患者。结果并未显示新联合治疗方案相对于经典治疗方案具有优势。两种治疗方案的复发率、患者退热所需时间和药物耐受性相似。经典治疗方案成本较低,但新联合治疗方案能让患者更舒适,因为每日服用的药丸数量减少至不到原来的一半,这一事实可能使其成为首选治疗方案。

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