Yano B L, Johnson K H, Hayden D W
Vet Pathol. 1981 Mar;18(2):181-7. doi: 10.1177/030098588101800205.
Amyloid in islets of Langerhans from 48 domestic cats, one human, one non-human primate, and one raccoon was compared with secondary systemic amyloid from three domestic cats, one dog, one human, and one cow to determine affinity for Congo red dye after treatment of paraffin-embedded tissue sections with potassium permanganate and dilute sulfuric acid. Insular amyloid from all six species was resistant to pretreatment with potassium permanganate, i.e., affinity for Congo red was retained, whereas secondary systemic amyloid from all species was sensitive to the potassium permanganate pretreatment. Other stains did not distinguish between insular and secondary systemic amyloid. The potassium permanganate-Congo red staining procedure thus can be used to differentiate insular from secondary systemic amyloid in the cat and other species. The results also indicate that insular amyloid and secondary systemic amyloid are of different chemical composition and pathogenesis.
将48只家猫、1个人、1只非人类灵长类动物和1只浣熊的胰岛中的淀粉样蛋白，与3只家猫、1只狗、1个人和1头牛的继发性全身性淀粉样蛋白进行比较，以确定在用高锰酸钾和稀硫酸处理石蜡包埋组织切片后对刚果红染料的亲和力。所有六个物种的胰岛淀粉样蛋白对高锰酸钾预处理具有抗性，即保留了对刚果红的亲和力，而所有物种的继发性全身性淀粉样蛋白对高锰酸钾预处理敏感。其他染色方法无法区分胰岛淀粉样蛋白和继发性全身性淀粉样蛋白。因此，高锰酸钾-刚果红染色程序可用于区分猫和其他物种的胰岛淀粉样蛋白和继发性全身性淀粉样蛋白。结果还表明，胰岛淀粉样蛋白和继发性全身性淀粉样蛋白具有不同的化学成分和发病机制。
