一种铜络合物在类风湿性关节炎发病机制中的可能作用。
Possible role of a copper complex in the pathogenesis of rheumatoid arthritis.
作者信息
Gerber D A
出版信息
Agents Actions Suppl. 1981;8:165-84.
PMID:7008552
Abstract
Clinical and experimental evidence suggest that rheumatoid arthritis may be due to a deficiency in joint fluid of an inhibitor of protein denaturation. This inhibitor may be a histidine-cystine-copper complex. A deficiency of this inhibitor may permit the nonimmunological alteration of joint fluid IgG to a pseudoimmune complex which could initiate the inflammation and immunological abnormalities of rheumatoid arthritis.
摘要
临床和实验证据表明，类风湿性关节炎可能是由于关节液中蛋白质变性抑制剂缺乏所致。这种抑制剂可能是一种组氨酸 - 胱氨酸 - 铜复合物。这种抑制剂的缺乏可能会使关节液中的免疫球蛋白G发生非免疫性改变，形成假免疫复合物，从而引发类风湿性关节炎的炎症和免疫异常。
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