Brady L J, Goodman M N, Kalish F N, Ruderman N B
Am J Physiol. 1981 Feb;240(2):E184-90. doi: 10.1152/ajpendo.1981.240.2.E184.
In contrast to adipose tissue and heart, the in vitro sensitivity of skeletal muscle to insulin is enhanced by starvation. To determine the basis for this, insulin binding and its ability to stimulate glucose metabolism were examined in the incubated rat soleus. In solei from 50-g rats, starvation for 48 h enhanced insulin binding by 50-100% at concentrations of 100 ng/ml or less. Starvation also resulted in higher basal and insulin-stimulated rates of glycogen synthesis, glycolysis, and glucose uptake. The enhanced effect of insulin only occurred at concentrations less than 50-75 ng/ml, in keeping with the increased binding of insulin in this concentration range. On the other hand, under conditions in which binding at equilibrium was the same, glucose uptake was still higher in the starved group, suggesting that some postreceptor event may have been more sensitive to insulin. These studies confirm that the in vitro sensitivity of rat skeletal muscle to insulin is enhanced by 48 h of starvation. They suggest that this is due at least partially to an increase in insulin binding at physiological concentrations.
与脂肪组织和心脏不同，饥饿可增强骨骼肌在体外对胰岛素的敏感性。为了确定其原因，对孵育的大鼠比目鱼肌进行了胰岛素结合及其刺激葡萄糖代谢能力的检测。在体重50克大鼠的比目鱼肌中，饥饿48小时后，在100纳克/毫升及以下浓度时，胰岛素结合增加了50%-100%。饥饿还导致基础和胰岛素刺激的糖原合成、糖酵解及葡萄糖摄取速率升高。胰岛素的增强作用仅在浓度低于50-75纳克/毫升时出现，这与该浓度范围内胰岛素结合增加一致。另一方面，在平衡结合相同的条件下，饥饿组的葡萄糖摄取仍较高，这表明某些受体后事件可能对胰岛素更敏感。这些研究证实，饥饿48小时可增强大鼠骨骼肌在体外对胰岛素的敏感性。研究表明，这至少部分归因于生理浓度下胰岛素结合的增加。
