Singh M P, Singh H, Kohli M S, Ahluwalia K S
Indian J Physiol Pharmacol. 1978 Apr-Jun;22(2):142-6.
Safety index (S.I.) of ether, chloroform and halothane was determined in mice following premedication with chloral hydrate, phenobarbitone, diazepam and trifluoperazine given alone or in combination with atropine or hyoscine. The S.I. of ether was significantly raised by chloral hydrate and phenobarbitone when combined with atropine while trifluoperazine in combination with atropine or hyoscine lowered it. The S.I. of chloroform and halothane was raised by chloral hydrate, phenobarbitone and diazepam. The S.I. raising effects were augmented in chloroform anaesthesia and reduced in cases of halothane (except diazepam-hyoscine) when these premedications were combined with atropine or hyoscine.
在单独给予或与阿托品或东莨菪碱联合给予水合氯醛、苯巴比妥、地西泮和三氟拉嗪进行预处理后，测定了小鼠体内乙醚、氯仿和氟烷的安全指数（S.I.）。当与阿托品联合使用时，水合氯醛和苯巴比妥可显著提高乙醚的安全指数，而三氟拉嗪与阿托品或东莨菪碱联合使用则会降低其安全指数。水合氯醛、苯巴比妥和地西泮可提高氯仿和氟烷的安全指数。当这些预处理药物与阿托品或东莨菪碱联合使用时，氯仿麻醉中安全指数的提高效果增强，氟烷麻醉中（地西泮 - 东莨菪碱组合除外）安全指数的提高效果减弱。
