Reinoso-Barbero F, Gutiérrez-Márquez M, Díez-Labajo A
Facultad de Medicina, Universidad Autónoma de Madrid, Departmento de Anestesiología, Hospital Infantil La Paz, Spain.
Paediatr Anaesth. 1998;8(3):195-9.
Eighty ambulatory surgical patients with ASA physical status 1 and 2, aged 1-10 years, were studied. One group received intranasal (IN) midazolam 0.25 mg.kg-1; a second group received IN 0.25 mg.kg-1 of midazolam plus 0.02 mg.kg-1 of atropine; the third group received 0.25 mg.kg-1 of midazolam plus 0.02 mg.kg-1 of atropine administered intramuscularly, and the fourth group received IN saline drops. All patients were anaesthetized with nitrous oxide, oxygen and halothane administered via mask. Heart rate (HR) was recorded every minute up to start of surgery. Children receiving midazolam had better preoperative sedation and anaesthesia induction scores. The IN administration of neither midazolam alone nor midazolam-atropine altered the incidence or degree of halothane-induced bradycardia.
对80名年龄在1至10岁、ASA身体状况为1级和2级的门诊手术患者进行了研究。一组接受0.25毫克/千克的鼻内（IN）咪达唑仑；第二组接受0.25毫克/千克的鼻内咪达唑仑加0.02毫克/千克的阿托品；第三组接受0.25毫克/千克的咪达唑仑加0.02毫克/千克的阿托品肌肉注射，第四组接受鼻内生理盐水滴剂。所有患者均通过面罩给予氧化亚氮、氧气和氟烷进行麻醉。在手术开始前每分钟记录心率（HR）。接受咪达唑仑的儿童术前镇静和麻醉诱导评分更好。单独鼻内给予咪达唑仑或咪达唑仑-阿托品均未改变氟烷诱导的心动过缓的发生率或程度。
