Arnold W, Vosteen K H
Arch Otorhinolaryngol. 1980;229(1):5-11. doi: 10.1007/BF00453747.
The IgG fraction was isolated from the serum of patients with nasopharyngeal carcinoma and conjugated with ferritin or horseradish peroxidase. The conjugate was injected i.v. in nude mice on which transplanted nasopharyngeal carcinomas were growing. Electron-microscopic examination of the tissue revealed localization of the antibodies of the IgG class (VCA, EBNA) exclusively within the tumor cell association of NPC transplants, mainly on the outer cell membrane, on mitochondria of the cytoplasm, and on the membranes of the endoplasmic reticulum. The possibility of conjugating such EBV-specific and thus NPC tumor cell-related antibodies with cytostatically active substances so as to convey the cytostatics directly to the tumor cells is discussed.
从鼻咽癌患者血清中分离出IgG组分，并将其与铁蛋白或辣根过氧化物酶结合。将这种结合物静脉注射到移植有正在生长的鼻咽癌的裸鼠体内。对组织进行电子显微镜检查发现，IgG类抗体（VCA、EBNA）仅定位在鼻咽癌移植瘤的肿瘤细胞团内，主要位于外细胞膜、细胞质的线粒体以及内质网的膜上。本文讨论了将此类EBV特异性且因此与NPC肿瘤细胞相关的抗体与具有细胞抑制活性的物质结合，从而将细胞抑制剂直接传递至肿瘤细胞的可能性。
