鼻后间隙癌中与爱泼斯坦-巴尔病毒相关的抗体模式
Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space.
作者信息
de Schryver A, Friberg S, Klein G, Henle W, Henle G, De-Thé G, Clifford P, Ho H C
出版信息
Clin Exp Immunol. 1969 Nov;5(5):443-59.
Sera from African patients with tumours of the post-nasal space, Hong Kong Chinese patients with carcinomas of the post-nasal space and from Indian donors with buccal, oro- and hypopharyngeal carcinomas, as well as African control sera from healthy persons and individuals with various non-neoplastic and neoplastic diseases were tested for anti-Epstein–Barr virus titres and for antibodies capable of blocking the direct membrane immunofluorescence reaction obtained between Epstein-Barr virus carrying lymphoblastoid cell lines and two different fluorescein conjugated reference sera; one from a patient with Burkitt lymphoma (F-Mutua conjugate) and the other from a patient with carcinoma of the post-nasal space (F-Kipkoech conjugate). Ninety per cent or more of the African and Chinese patients with carcinoma of the post-nasal space gave at least one high test, and 60% were high in all three assays. In contrast, African patients with post-nasal space tumours other than carcinomas, African controls and Indian buccal, oro- and hypopharyngeal carcinomas gave high reactions in all three assays in less than 20%.
检测了来自非洲后鼻道肿瘤患者、中国香港后鼻道癌患者以及印度颊、口腔和下咽癌捐赠者的血清，以及来自非洲健康人和患有各种非肿瘤性和肿瘤性疾病个体的对照血清，以检测抗爱泼斯坦 - 巴尔病毒滴度以及能够阻断携带爱泼斯坦 - 巴尔病毒的淋巴母细胞系与两种不同荧光素偶联参考血清之间直接膜免疫荧光反应的抗体；一种参考血清来自一名伯基特淋巴瘤患者（F - Mutua偶联物），另一种来自一名后鼻道癌患者（F - Kipkoech偶联物）。90%或更多的非洲和中国后鼻道癌患者至少有一项检测结果为高值，60%的患者在所有三项检测中结果均为高值。相比之下，非洲非癌性后鼻道肿瘤患者、非洲对照以及印度颊、口腔和下咽癌患者在所有三项检测中结果为高值的比例均低于20%。
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