de Merieux P, Spitler L E, Paulus H E
Arthritis Rheum. 1981 Jan;24(1):64-70. doi: 10.1002/art.1780240111.
The clinical response to levamisole in 11 patients with complete Behcet's syndrome was reviewed. Nine patients responded, 3 completely and 6 partially, with reduction in the number and severity of buccal and genital lesions. In 3 patients each, ocular inflammation and gastrointestinal involvement responded to levamisole, and in 1 patient neurologic status improved. Levamisole was purposely discontinued in 3 patients to assess its true role in disease control. Each patient experienced a flare. Reintroduction of therapy controlled the flare in all cases, although 1 patient subsequently relapsed while continuing therapy. Two patients failed to respond. Side effects necessitated permanent discontinuation of the drug in 2 respondent patients, but in no case did neutropenia or agranulocytosis develop. These preliminary results suggest that levamisole may be useful in the therapy of the various manifestations of Behcet's syndrome and that a controlled prospective study is indicated.
回顾了11例完全型白塞综合征患者使用左旋咪唑的临床反应。9例患者有反应，3例完全缓解，6例部分缓解，颊部和生殖器病变的数量和严重程度均有所减轻。3例患者的眼部炎症和胃肠道受累对左旋咪唑有反应，1例患者的神经状态有所改善。为评估左旋咪唑在疾病控制中的真正作用，特意让3例患者停药。每位患者病情均出现复发。重新开始治疗后，所有病例的复发均得到控制，不过有1例患者在继续治疗时随后复发。2例患者无反应。2例有反应的患者因副作用而永久停药，但无一例发生中性粒细胞减少或粒细胞缺乏症。这些初步结果表明，左旋咪唑可能对白塞综合征的各种表现形式的治疗有用，有必要进行一项对照前瞻性研究。
