Hamza M H
Clin Rheumatol. 1986 Sep;5(3):365-71. doi: 10.1007/BF02054255.
The clinical response to thalidomide in 30 male patients with Behçet's disease was reviewed. Twenty-six patients with orogenital ulcerations responded (20 completely and 6 partially). Cutaneous lesions including erythema nodosum or necrotic pseudofolliculitis were controlled by treatment in the majority of cases. All patients with arthritis responded (13 completely and 1 partially). Uveitis was improved in 3 patients, stabilizated in 4 and aggravated in 4. Patients with thalidomide purposely discontinued experienced a flare; the reintroduction of therapy controlled the flare. Side effects were uncommon and included skin rash and somnolence. These results suggest that thalidomide may be useful in the therapy of the various manifestations of Behçet's disease and that a controlled study is indicated.
回顾了30例男性白塞病患者使用沙利度胺的临床反应。26例有口生殖器溃疡的患者有反应（20例完全缓解，6例部分缓解）。包括结节性红斑或坏死性假毛囊炎在内的皮肤病变在大多数病例中通过治疗得到控制。所有关节炎患者均有反应（13例完全缓解，1例部分缓解）。3例葡萄膜炎患者病情改善，4例稳定，4例加重。故意停用沙利度胺的患者病情复发；重新开始治疗控制了复发。副作用不常见，包括皮疹和嗜睡。这些结果表明，沙利度胺可能对白塞病的各种表现形式的治疗有用，有必要进行对照研究。
