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骨髓瘤IgG和自身抗体的体外免疫吸附：一种临床可行的治疗方式。

Extracorporeal immunoadsorption of myeloma IgG and autoimmune antibodies: a clinically feasible modality of treatment.

作者信息

Ray P K, Besa E, Idiculla A, Rhoads J E, Bassett J G, Cooper D R

出版信息

Clin Exp Immunol. 1980 Nov;42(2):308-14.

PMID:7008987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537095/
Abstract

Using heat-killed, formalin-stabilized Staphylococcus aureus Cowan I suspension, it was possible to remove myeloma IgG and autoimmune anti-red blood cell antibodies from two patients' plasma following an extracorporeal procedure. The arterial anticoagulated blood was processed through a cell separator machine. The separated plasma was pumped through a bacterial filter containing S. aureus suspension. The adsorbed plasma was then reunited with the blood cells and returned to the patient through the vein. S. aureus Cowan I could selectively remove the myeloma IgG and autoimmune anti-red cell antibodies from the patients' plasma prolonging the lives of these two terminal patients. The immunoadsorption procedure appears to be a safe, practical and quick method for the removal of pathological IgG from the patients' plasma.

摘要

使用热灭活、福尔马林固定的金黄色葡萄球菌考恩I悬液，在体外操作后，有可能从两名患者的血浆中去除骨髓瘤IgG和自身免疫性抗红细胞抗体。动脉抗凝血液通过血细胞分离机进行处理。分离出的血浆被泵入含有金黄色葡萄球菌悬液的细菌过滤器。然后，吸附后的血浆与血细胞重新合并，并通过静脉返回患者体内。金黄色葡萄球菌考恩I能够从患者血浆中选择性地去除骨髓瘤IgG和自身免疫性抗红细胞抗体，从而延长了这两名晚期患者的生命。免疫吸附程序似乎是一种从患者血浆中去除病理性IgG的安全、实用且快速的方法。

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本文引用的文献

1
Occurrence of protein a in staphylococcal strains: quantitative aspects and correlation to antigenic and bacteriophage types.葡萄球菌株中蛋白 A 的出现：定量方面及其与抗原和噬菌体型的相关性。
Infect Immun. 1971 Jan;3(1):10-5. doi: 10.1128/iai.3.1.10-15.1971.
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SEROLOGY OF ACQUIRED HEMOLYTIC ANEMIAS.获得性溶血性贫血的血清学
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Quantitation of staphylococcal protein A: Determination of equilibrium constant and number of protein A residues on bacteria.葡萄球菌蛋白A的定量：平衡常数及细菌上蛋白A残基数量的测定。
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Intensive plasmapheresis as a therapeutic measure in Rhesus-immunised women.强化血浆置换作为恒河猴免疫女性的一种治疗措施。
Lancet. 1970 Apr 18;1(7651):793-8. doi: 10.1016/s0140-6736(70)92406-2.
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A rapid slide-agglutination method for typing pneumococci by means of specific antibody adsorbed to protein A-containing staphylococci.一种通过吸附于含蛋白A葡萄球菌上的特异性抗体对肺炎球菌进行分型的快速玻片凝集法。
J Med Microbiol. 1973 May;6(2):187-90. doi: 10.1099/00222615-6-2-187.
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Capillary tube testing and enhancement with 30% Albumin.毛细管测试及用30%白蛋白增强。
Vox Sang. 1976;30(2):144-8. doi: 10.1111/j.1423-0410.1976.tb02805.x.
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Plasmapheresis and immunosuppressive drug therapy in myasthenia gravis.重症肌无力的血浆置换和免疫抑制药物治疗
N Engl J Med. 1977 Nov 24;297(21):1134-40. doi: 10.1056/NEJM197711242972102.
10
Plasmapheresis in Goodpasture's syndrome with renal failure.伴有肾衰竭的肺出血肾炎综合征的血浆置换疗法。
Med J Aust. 1977 Jun 11;1(24):875-9. doi: 10.5694/j.1326-5377.1977.tb131209.x.

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