骨髓瘤IgG和自身抗体的体外免疫吸附：一种临床可行的治疗方式。

Extracorporeal immunoadsorption of myeloma IgG and autoimmune antibodies: a clinically feasible modality of treatment.

作者信息

Ray P K, Besa E, Idiculla A, Rhoads J E, Bassett J G, Cooper D R

出版信息

Clin Exp Immunol. 1980 Nov;42(2):308-14.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537095/

Abstract

Using heat-killed, formalin-stabilized Staphylococcus aureus Cowan I suspension, it was possible to remove myeloma IgG and autoimmune anti-red blood cell antibodies from two patients' plasma following an extracorporeal procedure. The arterial anticoagulated blood was processed through a cell separator machine. The separated plasma was pumped through a bacterial filter containing S. aureus suspension. The adsorbed plasma was then reunited with the blood cells and returned to the patient through the vein. S. aureus Cowan I could selectively remove the myeloma IgG and autoimmune anti-red cell antibodies from the patients' plasma prolonging the lives of these two terminal patients. The immunoadsorption procedure appears to be a safe, practical and quick method for the removal of pathological IgG from the patients' plasma.

摘要

使用热灭活、福尔马林固定的金黄色葡萄球菌考恩I悬液，在体外操作后，有可能从两名患者的血浆中去除骨髓瘤IgG和自身免疫性抗红细胞抗体。动脉抗凝血液通过血细胞分离机进行处理。分离出的血浆被泵入含有金黄色葡萄球菌悬液的细菌过滤器。然后，吸附后的血浆与血细胞重新合并，并通过静脉返回患者体内。金黄色葡萄球菌考恩I能够从患者血浆中选择性地去除骨髓瘤IgG和自身免疫性抗红细胞抗体，从而延长了这两名晚期患者的生命。免疫吸附程序似乎是一种从患者血浆中去除病理性IgG的安全、实用且快速的方法。

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