Koike Y, Togashi H, Shimamura K, Yomaida I, Saito H
Clin Exp Hypertens (1978). 1981;3(1):103-20. doi: 10.3109/10641968109037171.
Present experiments were undertaken to compare the effects of clonidine and guanfacine withdrawal on blood pressure in spontaneously hypertensive rats. Five week oral administration of clonidine at a dose of approximately 300 microgram/kg/day produced a significant hypotension. After acute interruption of clonidine administration, a marked blood pressure rise was observed. Peak blood pressure rise was reached within 24 hours after clonidine withdrawal. A significant increase in plasma norepinephrine concentration was observed when clonidine treatment was discontinued. On the other hand, long-term administration of guanfacine at a dose of approximately 3 mg/kg/day produced a significant hypotension. After a five week administration of guanfacine, abrupt cessation did not produce a rapid blood pressure rise. Catecholamine concentration in urine and plasma was not influenced either by guanfacine administration or its withdrawal.
开展本实验以比较可乐定和胍法辛撤药对自发性高血压大鼠血压的影响。以约300微克/千克/天的剂量口服可乐定5周可产生显著的低血压。急性中断可乐定给药后，观察到血压显著升高。可乐定撤药后24小时内血压升至峰值。停用可乐定治疗后，血浆去甲肾上腺素浓度显著增加。另一方面，以约3毫克/千克/天的剂量长期服用胍法辛可产生显著的低血压。服用胍法辛5周后，突然停药未导致血压快速升高。胍法辛的给药或撤药对尿液和血浆中的儿茶酚胺浓度均无影响。
