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β-内啡肽：对大鼠的抗利尿作用

betah-endorphin: antidiuretic effects in rats.

作者信息

Tseng L F, Loh H H, Li C H

出版信息

Int J Pept Protein Res. 1978 Sep;12(3):173-6. doi: 10.1111/j.1399-3011.1978.tb02882.x.

DOI:10.1111/j.1399-3011.1978.tb02882.x
PMID:700922
Abstract

Human beta-endorphin (betah-EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, betah-EP is 24 times more potent than morphine. Intraventricularly, betah-EP is 24 times more potent than morphine. Intraventricularly, betah-EP is effective at doses (0.45 microgram) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of betah-endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of betah-endorphin.

摘要

人β-内啡肽（β-EP）可抑制大鼠的尿流。该肽的这种抗利尿作用在静脉注射和脑室内注射后均会出现。静脉注射时，β-EP的效力比吗啡强24倍。脑室内注射时，β-EP的效力比吗啡强24倍。脑室内注射时，β-EP在剂量为0.45微克时有效，而静脉注射该剂量则无抗利尿活性。这一事实表明，β-内啡肽抗利尿作用的一个部位可能在中枢神经系统。对吗啡耐受的动物对β-内啡肽的抗利尿作用也具有耐受性。

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引用本文的文献

1
beta-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and rabbits.β-内啡肽：大鼠和兔子静脉注射氚标记肽后的稳定性、清除行为及进入中枢神经系统的情况。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4588-91. doi: 10.1073/pnas.77.8.4588.
2
Antidiuretic effect of beta-endorphin and morphine in Brattleboro rats: development of tolerance and physical dependence after chronic morphine treatment.β-内啡肽和吗啡对布拉特洛维大鼠的抗利尿作用：慢性吗啡治疗后耐受性和身体依赖性的发展
Br J Pharmacol. 1980;71(1):51-6. doi: 10.1111/j.1476-5381.1980.tb10908.x.
3
Morphine and opioid peptides reduce paraventricular neuronal activity: studies on the rat hypothalamic slice preparation.吗啡和阿片肽降低室旁核神经元活动：对大鼠下丘脑脑片标本的研究。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5527-31. doi: 10.1073/pnas.77.9.5527.

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