Richter E A, Galbo H, Christensen N J
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jan;50(1):21-6. doi: 10.1152/jappl.1981.50.1.21.
We have previously shown that adrenodemedullation combined with chemical sympathectomy decreases the exercise-induced muscular glycogen breakdown in rats. Now we have elucidated to what extent the effect of combined adrenodemedullation and sympathectomy can be ascribed to the lack of either the adrenal medulla or of the peripheral sympathetic nerve endings. Rats were either adrenodemedullated or underwent sham operation and subsequent unilateral hindleg sympathectomy. Three weeks after adrenodemedullation and 1 wk after sympathectomy, the rats either rested or swam with a tail weight for 75 min or continued swimming to exhaustion. The exercise-induced muscular glycogenolysis was markedly impeded by adrenodemedullation but not by sympathectomy. During the first 75 min of exercise, hepatic glycogenolysis was decreased in adrenodemedullated rats compared with sham-operated rats, and blood glucose only increased in the latter. At exhaustion, plasma insulin and glucagon were higher and lower, respectively, in adrenodemedullated rats than in sham-operated rats, whereas blood glucose did not differ significantly between these groups. During prolonged swimming in rats, adrenomedullary hormones enhance muscular glycogenolysis, glucagon secretion, and the early hepatic glycogenolysis but inhibit insulin secretion.
我们之前已经表明，肾上腺髓质切除术联合化学性交感神经切除术可减少大鼠运动诱导的肌肉糖原分解。现在我们已经阐明，肾上腺髓质切除术和交感神经切除术联合作用的效果在多大程度上可归因于肾上腺髓质或外周交感神经末梢的缺失。将大鼠进行肾上腺髓质切除术或假手术，随后进行单侧后肢交感神经切除术。肾上腺髓质切除术后3周和交感神经切除术后1周，大鼠要么休息，要么拖着尾巴负重游泳75分钟，要么继续游泳直至精疲力竭。运动诱导的肌肉糖原分解受到肾上腺髓质切除术的显著阻碍，但不受交感神经切除术的影响。在运动的前75分钟内，与假手术大鼠相比，肾上腺髓质切除大鼠的肝糖原分解减少，且仅后者的血糖升高。在精疲力竭时，肾上腺髓质切除大鼠的血浆胰岛素水平高于假手术大鼠，而胰高血糖素水平低于假手术大鼠，而这些组之间的血糖没有显著差异。在大鼠长时间游泳期间，肾上腺髓质激素增强肌肉糖原分解、胰高血糖素分泌和早期肝糖原分解，但抑制胰岛素分泌。
