Liu H S, Refojo M F, Perry H D, Albert D M
Invest Ophthalmol Vis Sci. 1978 Oct;17(10):993-1004.
Two anticancer agents, one lipophilic, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and one hydrophilic, 5-(3,3-dimethyl-1-triazeno) imidazol-4-carboxamide (DTIC), were used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. The BCNU test animals were divided into three groups: one treated by direct injection of the drug into the subconjuntival space or the anterior chamber, the second by both direct injections and intravenous administration, and the third by intravenous injection alone. The DTIC test animals were treated with only local injection into the subconjunctival space or anterior chamber. Dosage, delivery system, and effectiveness were compared following clinical observation and histopathologic examination. Direct delivery of BCNU or DTIC in subconjuntival space or anterior chamber delayed the growth of Brown-Pearce epithelioma in rabbit eye. The effectiveness of this treatment was significnatly enhanced by combining direct injection with systemic administration of a lower dose of BCNU.
两种抗癌药物，一种亲脂性的1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀，BCNU）和一种亲水性的5-（3,3-二甲基-1-三氮烯）咪唑-4-甲酰胺（达卡巴嗪，DTIC），被用于治疗兔眼前房中的布朗-皮尔斯上皮瘤。卡莫司汀试验动物被分为三组：一组通过将药物直接注射到结膜下间隙或前房进行治疗，第二组通过直接注射和静脉给药两种方式，第三组仅通过静脉注射。达卡巴嗪试验动物仅通过结膜下间隙或前房局部注射进行治疗。在临床观察和组织病理学检查后，对剂量、给药系统和有效性进行了比较。将卡莫司汀或达卡巴嗪直接递送至结膜下间隙或前房可延缓兔眼布朗-皮尔斯上皮瘤的生长。通过将直接注射与较低剂量的卡莫司汀全身给药相结合，这种治疗的有效性得到了显著提高。
